Stack Attack for Kira and Health for Sisko. Miles will be effective at lower than the reccomended level but far more potent from rank 3. Sisko Full Synergy, Offers a Higher mitigation boost than 5 of eleven, and this may be over kill as the limit is c. 71.2%. if you can get to that figure with one side of synergy, consider swapping out Kira for another officer such as Khan, lorca or six of eleven (if using six, then would need to stack some attack to increase effectivness)